Anti-Poly(glycerolphosphate) in Human Sera

Properties of Various Anti-γ-globulin Factors in Human Sera

The serological and physicochemical properties of the following three forms of human anti-gamma-globulin factors were compared: (a) rheumatoid factors; (b) Milgrom type anti-gamma-globulin factors; and (c) factors directed against an antigen in human gammaG-globulin that is hidden in the intact molecule and revealed by enzymatic digestion at low pH. The property common to these factors is abili...

Incidence of the anti-nuclear factor in human sera.

Miescher and Fauconnet (1954) reported that the ability of serum from patients suffering from disseminated lupus erythematosus (D.L.E.) to induce the formation of L.E. cells was abolished if the serum was previously incubated with nuclear material. Friou (1957), using the Coons' technique, showed that cells in unfixed sections of tissue exposed to serum from patients with D.L.E. and, subsequent...

Anti- Idiotype Sera Raised

Present concepts of the maturation of a B-lymphocytic clone involve progressive changes in cellular morphology and mode of immunoglobulin (Ig) production. The ancestral small lymphocyte synthesizes Ig for insertion into its plasma membrane, while those of its descendants destined to produce humoral antibody show first a superimposed synthesis of Ig for export and finally a heavy export with lit...

An acceptor-dependent polyglycerolphosphate polymerase.

A method for the extraction of polyglycerolphosphate polymerase from Bacillus subtilis membranes is described. Further purification by ion-exchange chromatography yields an enzyme fraction totally dependent on the addition of a heat-stable factor for activity. This factor was isolated from cell membranes and acts as an acceptor of glycerolphosphate units. The acceptor contains glycerolphosphate...

Leukocyte antibodies in human sera and in immune rabbit sera.